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'ManuscriptPro PDF Search' digitally communicates with online databases that contain selected information from scientific journals. This information may allow for rapid identification of non-responders in male hormonal contraceptive trials. Early suppression of gonadotropins is associated with, but does not ensure, adequate suppression of spermatogenesis. Serum nestorone concentrations were significantly associated with suppression, but serum testosterone concentrations were not. Indeed, luteinizing hormone or follicle-stimulating hormone concentrations greater than 1 IU/L after 4 weeks of transdermal testosterone/nestorone treatment were 97% sensitive for predicting failure to suppress spermatogenesis after 24 weeks of treatment. We hypothesized that serum hormone and gonadotropin concentrations after 4 weeks of transdermal treatment with testosterone and Nestorone in a contraceptive trial would be associated with suppression of sperm concentrations to <1 million/mL after 24 weeks.
Methods to identify incomplete suppressors early in treatment might identify men most responsive to male hormonal contraceptives.
M Y Roth, N Ilani, C Wang, S T Page, W J Bremner, R S Swerdloff, C Dart, R Sitruk-Ware, N Kumar, D Blithe, J K Amory,ĭevelopment of a male hormonal contraceptive has been challenging ascribable to the failure to adequately suppress spermatogenesis in 5-10% of men. PMCID: PMC4151496 ( free full text version available ) Download PDF Characteristics associated with suppression of spermatogenesis in a male hormonal contraceptive trial using testosterone and Nestorone(®) gels.PMID: 24123845 ( view PubMed database entry )ĭOI: 10.1111/j. ( read at publisher's website )
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